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Sulfotransferases in the bioactivation of xenobiotics science

Dec 1, Xenobiotic-metabolizing sulfotransferases are cytosolic enzymes, which form a superfamily (SULT). Eleven distinct human SULT forms are known, which strongly differ in their tissue distribution and their substrate specificity. Common functionally relevant genetic polymorphisms of the transcribed region are. Chem Biol Interact. Dec 1;() Sulfotransferases in the bioactivation of xenobiotics. Glatt H(1). Author information: (1)Department of Toxicology, Deutsches Institut für Ernährungsforschung (DIfE), Arthur-Scheunert- Allee , D, Potsdam-Rehbrücke, Germany. [email protected] Conjugation of. Abstract. Sulfonation is an important reaction in the metabolism of numerous xenobiotics, drugs, and endogenous compounds. However, many of these enzymes are also capable of bioactivating procarcinogens to reactive electrophiles. In humans Molecular biology of the human phenol sulfotransferase gene family.

Xenobiotic-metabolizing sulfotransferases are cytosolic enzymes, which form a superfamily (SULT). Eleven distinct human SULT forms are known, which strongly differ in their tissue distribution and their substrate specificity. Common functionally relevant genetic polymorphisms of the transcribed region are known for two of. Oct 26, scientific article (publication date: December ). Sulfonation is an important reaction in the metabolism of numerous xenobiotics, drugs, and endogenous compounds. Toxicological Sciences, Volume 90, Issue 1, 1 March , Pages 5–22, A supergene family of enzymes called sulfotransferases (SULTs) catalyze this reaction.

Feb 15, Keywords sulfonation, PAPSS, sulfotransferases, heparan. Human Sulfotransferases and Their Role in Chemical Metabolism Niranjali Gamage. The Internal Medicine Review. Glatt HSulfotransferases in the bioactivation of xenobiotics. AA, require sulfotransferase SULTcatalyzed. Heterologous systems for. 4 Bioactivation by. Phase-II-Enzyme-Catalyzed. Conjugation of Xenobiotics. MARK P. GRILLO. Department of Pharmacokinetics and Drug Metabolism, Amgen, . (nitrenium ion). N-HydroxyAAF. Sulfonation. Sulfotransferases. PAPS. Benzylic alcohols. Benzylic sulfonate esters. (benzylic carbocation). 7-OH- DMBA. Dec 19, environment toxicants) (Liu et al., ;James and Ambadapadi, ), but also bioactivation of certain drugs to give toxic reactive intermediates (Shibutani et al., ;Glatt, ). Inhibition of sulfotransferases by xenobiotics may lead to drug- drug interactions and perturbation in homeostasis of.

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