Right First Time in Fine-Chemical Process Scale-Up: Avoiding Scale-Up Problems: The Key to Rapid Success. John Blacker. Institute of Process R&D, University of Leeds, U.K.. Org. Process Res. Dev., , 17 (9), pp – DOI: /opg. Publication Date (Web): August 12, Copyright © Buy Right First Time in Fine-Chemical Process Scale-Up: Avoiding Scale-Up Problems: the Key to Rapid Success on ✓ FREE SHIPPING on qualified orders. Right First Time in Fine-Chemical Process Scale-Up: Avoiding Scale-Up Problems: The Key to Rapid SuccessRight First time in Fine-Chemical Process Scale-Up: Avoiding Scale-Up Problems: The Key to Rapid Success, Lumbertus A . Hulshof. Scientific Update LLP: Mayfield, U.K., + xii pp. £
makes these processes similar, you can eliminate many scale-up problems. A rational approach to scale-up has been used in physical sciences, viz. fluid. dynamics and chemical engineering, for quite some time. This approach is based . on process similarities between different scales and employs dimensional analy -. Towards this end, recent experimental and engineering efforts have been devoted to the implementation of continuous MSMPR crystallisers for pharmaceutical and fine chemical compounds. For example, Sen et al.  optimised the start-up of a continuous pharmaceutical manufacturing process, wherein the cooling. 7 Nov This allowed us to rapidly produce many different prototypes and to optimize experimentally key design aspects in a time-efficient fashion. This excellent flow distribution was crucial to scale up a model reaction efficiently, displaying yields comparable to those obtained in a single-channel device. We also.
importance to scale-up), It was also demonstrated that none of the published em- for various chemical processes (Mashelkar, ; Shah et al., .. key D(m) Hlm ). U, (m/s). Figure 6. Gas holdup in mono-ethylene glycol vs. su- perficial (nitrogen) gas velocity at. Abstract. The use of dimensional analysis to scale-up mechanically agitated flotation processes and to identify first order kinetic models expressing recovery (R) as a function of time (τ) such that: R = Rm (1-e-kτ). (1) circulation ŘCirc = Qc/Qp is a quick indication of whether sanding-up problems can be a' a cb c' inlet. The first step in developing fuel cells is to enhance the hydrogen storage. Hydrogen can be com- pressed and reversibly stored in tanks through chemical or . ). The major challenge for development of such systems is their scale- up. Scale-up of manufacturing processes for nanostructures to technological scales has.